Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles
نویسندگان
چکیده
منابع مشابه
Synthesis and antimicrobial properties of novel 2,5-disubstituted 1,3,4-oxadiazoles
The search for better antimicrobial agent due to rapid appearance of multidrug resistant microorganism and antimicrobial properties of semicarbazones and 2,5-disubstituted 1,3,4-oxadiazoles prompted us to undertake the synthesis of a few novel N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-(4substitutedbenzaldehyde)-semicarbazone and N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-[1-(4s...
متن کاملReaction of 2 , 5 - Disubstituted - l , 3 , 4 - oxadiazoles
Some 5-aryl-2-mercapto-1,3,4-oxadiazole (I) reacted with maleic anhydride, maleic acid and p-benzoquinone affording 2-(5-aryl-1,3,4-oxadiazol-2-ylthio)succinic anhydrides (II), 2-(5-aryl-1,3,4-oxadiazol-2-ylthio)succinic acids (III) and 2-(2,5-dihydroxyphenylthio)-5-aryl-l,3,4-oxadiazoles (IV), respectively. Treatment of 2-methylthio-5-phenyl-l,3-oxadiazole (V) with amines gives 2-[(alkyl or ar...
متن کاملA Simple, Practical and Efficient Method for the Synthesis of New Disubstituted 1,3,4-oxadiazoles
Reactions of N-isocyaniminotriphenylphosphorane with α- chloroketones in the presence ofaromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions toafford new disubstituted 1,3,4-oxadiazole derivatives in high yields.
متن کاملSynthesis and Characterization of New 2,5-disubstituted-1,3,4- oxadiazoles as Possible Biological Active Compounds
GABRIELA LAURA ALMAJAN1*, STEFANIA-FELICIA BARBUCEANU1, ILEANA FARCASANU2, CONSTANTIN DRAGHICI3 1 University of Medicine and Pharmacy, Faculty of Pharmacy, Organic Chemistry Department, 6 Traian Vuia Street, 020956 Bucharest, Romania 2 University of Bucharest, Faculty of Chemistry, Organic Chemistry, Biochemistry and Catalysis Department, 90-92 Sos. Panduri, 050663, Bucharest, Romania 3 Romania...
متن کاملExpanding medicinal chemistry space.
Clinically useful drugs target a relatively small number of proteins that lie within a clearly defined and chemically accessible space. However, many high value biological targets lie outside this chemical space, and an ability to access such 'intractable' targets not amenable to traditional small molecule intervention would expand treatment options and be a major boost for patients and the pha...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2016
ISSN: 2156-8952,2156-8944
DOI: 10.1021/acscombsci.6b00103